Comparison of the Effects of Prednisolon, Danazol and Testosteron Propionat Therapy in Dogs with Immune Mediated Hemolytic Anemia and Thrombocytopenia

The purpose of the study was to determine and compare the effectiveness of Prednisolon, Danazol and Testosteron propionate in the treatment of 45 dogs with IMHA and IMT. All dogs were selected from dogs diagnosed IMHA and IMT at the Uludag University Faculty of Veternary Medicine, Internal Medicine Clinic, 2003 and 2007 years comprised the animal population of the study. Clinical, biochemical and hematological examination were performed to all dogs during 3 weeks. Dogs in the present study were divided into 3 groups which consisted of 15 dogs. Group I received prednisolone at immunosuppressive doses. Group II received Danazol and also group III received testosterone propionate. The mainly manifesting disturbances in presentation were exercise intolerans, pale mucous membranes, icterus, hemoglobinuria, petechiae and ecchymosis, melena and epistaxis. Hemoglobin and hematocrit levels were significantly higher in group I and II compared with group III at the end of treatment (P=0.05). Thrombocyte counts were within normal reference limits in group I and II at the end of the therapy. In conclusion in this study, despite the normal response to conventional treatment, prednisolone therapy and danazol as synthetic androgen, it was deterimined that there were no anticipated effects by testosterone propionate for treatment of AIHA in dogs.